2025 Energy HPC Conference

We will present an overview of the Oak Ridge National Laboratory's Artificial Intelligence Initiative, which aims to advance the domains of science, energy, and national security. At the core of this initiative are two fundamental thrusts: transformative science applications and cross-cutting assurance. The application thrust focuses on developing AI methods to accelerate scientific discoveries, while the cross-cutting assurance thrust ensures that AI systems are secure, trustworthy, and energy-efficient. Secure approaches include alignment, privacy preservation, and robustness testing for AI models. Trustworthiness is achieved through validation and verification processes coupled with advanced techniques in uncertainty quantification and causal reasoning. Meanwhile, energy efficiency is prioritized by developing scalable solutions, integrating edge computing technologies, and adopting a holistic co-design approach that optimizes the synergy between software and hardware resources.